Ubiquitin and Disease (Molecular Biology Intelligence Unit)

The book deals with the understanding of the molecular basis of diseases where defects in ubiquitin gene expression and/or synthesis are involved. Among these, Alzheimer's and other neurodegenerative diseases, muscle dystrophies, cancer, muscle wasting and autoimmune diseases.

The importance of the ubiquitin-dependent proteolysis is also studied in aging and a special emphasis is put in understanding the regulation of this ATP-dependent proteolytic system in order to design future therapeutic strategies.

19 figures, 14 tables

TOC

Part I Introduction Chapter 1 Proteolysis: A Pleyade of Systems Chapter 2 The Ubiquitin System and Proteolysis Part II Ubiquitin and Disease Chapter 3 Alzheimer and other Neurodegenerative Diseases Chapter 4 Cancer Chapter 5 Muscle Wasting and Dystrophies Chapter 6 Other Pathological States Chapter 7 Aging Chapter 8 The Role of other Proteolytic Systems in Disease Chapter 9 Cell Injury and Cell Death: Apoptosis Part III Regulation and Therapeutic Implications Chapter 10 The Regulation of the UB System Chapter 11 The Design of Therapeutic Strategies