ACABS

Thursday, 28th April
Registration
Main Foyer, Carrillo Gantner Theatre
8:00 AM - 5:00 PM


Opening Ceremony

Carrillo Gantner Theatre







8:30 AM - 10:00 AM

Chaired by Prof Zihe Rao and Prof Jun-Ping Liu


Speakers:
His Excellency Prof David de Kretser
Mr Weiqiang Shen, Consul General of the Consulate General of People's Republic of China in
Melbourne
Dr Kathy Alexander, CEO, The City of Melbourne
Prof Qimin Zhan, Vice President, Chinese Academy of Medical Sciences, Beijing Union Medical
University
Prof Tam Sridhar, Vice-President (India and China Research Institutes), Monash University
Prof Xuejun Zhang, President, Anhui Medical University
Prof Julianne Reid, Deputy Pro-Vice Chancellor, RMIT University
Prof Lei Yang, Vice President, Hangzhou Normal University
Prof Geoff McColl, Deputy Dean, Faculty of Medicine, Dentistry and Health Sciences
The University of Melbourne
Representative of the State Government

Plenary Lecture
Plenary Session P1 Carrillo Gantner Theatre
10:00 AM - 12:50 PM

Chaired by Prof Jun-Ping Liu


10:00am
Killer Viruses and Killer T Cells


Professor Peter Doherty
10:35am
Structure and function of the coronavirus replication and transcription machinery


Professor Zihe Rao

Morning Tea










11:10 AM - 11:30 AM
Chaired by Prof Arthur Shulkes


11:30am
Phosphoinositide 3-kinase (PI3K) regulation of cytokine trafficking and secretion

Professor Jennifer Stow
12:00am
Centrosomal Nlp in the control of mitotic progression and tumorigenesis

Prof. Qimin Zhan
12:30am
Control of the apoptotic switch by the Bcl-2 family

Prof David Huang












Special presentation
Changzhou, a city welcoming biopharm innovations
Yasuko Hiraoka Myer Room






1:00 AM - 1:20 AM

---

Lunch

1:00 PM - 1:50 PM


Cancer Biology and Therapies
Concurrent Session C1 Yasuko Hiraoka Myer Room



1:50 PM - 5:10 PM

Chaired by Prof Richard Simpson and Dr Hongjian Zhu



1:50pm
Characterization of Human Colon Carcinoma Cell Line LIM1863-Derived Extracellular
Vesicles: Evidence for the Participation of Different Cellular Trafficking Pathways in
Exosome Exocytosis

Prof Richard Simpson
2:10pm

Applications of HDAC and HDAC Inhibitors in Cancer Research

Prof Weiguo Zhu








2:30pm
ATM and Senataxin defective in autosomal recessive ataxias protect against
neurodegeneration

Prof. Martin Lavin
2:50pm

Autologous Cytotoxic T cell-based Adoptive Immunotherapy for Epstein-Barr virus
Associated Nasopharyngeal Carcinoma in Hong Kong Chinese patients

Prof Rajiv Khanna

Afternoon Tea

3:10 PM - 3:30 PM
Chaired by Prof Judeth Clements and Prof Yuxin Yin

3:30pm

A Novel Concept of SNVs Derived from Exomic Sequencing to Identify Frequent
Mutations in Gastric Cancer

Prof Youyong Lu
3:50pm
Understanding the role of kallikrein-related peptidases in prostate and ovarian cancer: Use
of novel biomimetic models and a systems biology approach


Prof Judith Clements








4:10pm
Interleukin-11, a therapeutic target linking inflammation to gastrointestinal cancer

A/Prof Matthias Ernst

4:30pm
Targeting CD146 antibody inhibits tumor angiogenesis and tumor growth

Prof Xiyun Yan
4:50pm
Defining the consensus substrate phosphorylation sequence of CSK-Homologous Kinase
reveals conformity of determinants recognized by both the active site and the SH2 domain

A/Prof Heung-Chin Cheng
5:10pm
TBA

Prof. Zichun Hua




Immunology
Concurrent Session C2 Carrillo Gantner Theatre




1:50 PM - 5:10 PM

Chaired by Prof Zhanguo Li and A/Prof Wesan Chen

1:50pm
Influenza in 2011: what has happened to the H1N1 pandemic virus?

Professor Anne Kelso
2:10pm
Activated Allogeneic NK Cells as Suppressors of Host Alloreactive Responses


Prof Haiyan Liu







2:30pm
TCR diversity and CD1d-glycolipid antigen recognition

---

Prof. Dale Godfrey
2:50pm
ECM1 controls Th2 cell egress from lymph nodes through re-expression of S1P1


Prof Bing Sun

Afternoon Tea

3:10 PM - 3:30 PM
Chaired by Prof Haiyan Liu and Prof Dale Godfrey

3:30pm
Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of
rheumatoid arthritis
Prof Zhanguo Li
3:50pm
The role of PRMT5 in human fetal globin gene silencing
Prof Quan Zhao
4:10pm
Sialoside-based Pattern Recognitions Discriminating Infections from Tissue Injuries

Prof. Yang Liu
4:30pm
Development of novel, point-of-care tests for infectious disease diagnosis and
management


A/Prof. David Anderson
4:50pm
mTOR Activation Underlies Hematopoietic Stem Cell Defects in Autoimmune Diseases,
Inflammation and Aging

A/Prof. Pan Zheng
5:10pm
Critical roles of PI3K and Akt in the low molecular weight hyaluronan-induced acute lung
inflammation.

Prof Liyun Shi

Special Event
TBA










6PM - 8PM

Friday, 29th April
Registration
Main Foyer Carrillo Gantner Theatre
8:30 AM - 5:00 PM


Plenary Lecture
Plenary Session P2 Carrillo Gantner Theatre
9:00 AM - 11:00 AM

Chaired by Prof Rob Saint and Prof. Qimin Zhan

9:00am
Mapping the insulin signalling network in Adipocytes


Professor David James
9:30am
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition


Professor Kou-Juey Wu
10:00am
Essential but toxic: Controlling the flux of iron in the body


Professor Greg Anderson
10:30am
BioArchitecture, the actin cytoskeleton and a new therapeutic opportunity

Prof. Peter Gunning

Morning Tea










11:00 AM - 11:30 AM
11:30am
The Past, Present and Perspective of Genome-wide Association Study

Prof. Xuejun Zhang
12:00am
Negative regulation of Wnt signaling by autophagy


Prof. Ye-Guang Chen

---

Special presentation
Yasuko Hiraoka Myer Room






12:20 AM - 12:40 AM


Lunch

12:30 PM - 1:30 PM

Metabolic disorders, diabetes and obesity
Concurrent Session C3 Carrillo Gantner Theatre



1:30 PM - 3:50 PM



Chaired by Prof Sof Andrikopolous and A/Prof Jiming Ye

1:30pm
Effects of Fatty Acids on Skeletal Muscle Glucose Uptake: Two Sides of the Coin

Prof Pingsheng Liu
1:50pm
ARNT and its partners in beta-cell function and diabetes


Prof Jenny Gunton
2:10pm
Protein S-nitros(yl)ation in nuclear protein export regulation





Prof Chang Chen
2:30pm
Turning up the heat: role of heat shock proteins in metabolic disease

Prof. Mark Febbraio
2:50pm
The Islet Beta Cell In Type 2 Diabetes - Why Hard Work Doesn't Always Pay Off


Prof Sof Andrikopolous
3:10pm

Role of TGF-/Smad signaling in diabetic nephropathy


Prof Huiyao Lan
3:30pm
RORalpha, a novel regulator of adiposity and insulin signaling


Prof. George Muscat


Cardiovascular and Renal diseases
Concurrent Session C4 Yasuko Hiraoka Myer Room


1:30 PM - 3:30 PM

Chaired by Prof Jaye Chin-Dusting and Dr. Bing Wang

1:30pm
Heart-Kidney Interactions in LV Dysfunction

Prof. Henry Krum
1:50pm
Endothelial markers in Obesity

Prof. Jaye Chin-Dusting






2:10pm
Catalytic DNA as New Drugs for Vascular Disease and Cancer

Prof Levon Khachigian
2:30pm
Mechanism of Improvement in Vagus against Myocardial Ischemic Injury


Prof. Weijin Zang
2:50pm
Gene therapy for the failing heart


Prof David Kaye
3:10pm
Advances in Cardiac Tissue Engineering from Stem Cells- How to mend a broken heart


Prof. Greg Dusting


Afternoon Tea

3:30 PM - 4:00 PM





Cell Signalling & Development Biology
Concurrent Session C5 Carrillo Gantner Theatre



4:00 PM - 6:20 PM

Chaired by Prof Richard Cotton and Prof Pingsheng Liu

---

4:00pm
The Human Variome Project - Collection of Variation Worldwide
Prof Richard Cotton
4:20pm
Molecular genetic and genomic dissection of zebrafish circadian clocks
Prof Han Wang
4:40pm
Newwork of p53 and PTEN: System biology of the genome


Prof. Yuxin Yin
5:00pm
Actions of insulin-like growth factor binding protein-6 in cancer cells

Prof. Leon Bach






5:20pm
Clinical Validation of BCL2 as a Therapeutic Target in CLL and other B cell malignancies


Prof Andrew Roberts
5:40pm
Cell division: mechanisms and consequences

Prof Rob Saint
6:00pm
Dissection of endosome-to-Golgi retrograde transport pathways relevant to physiological
processes


Prof. Paul Gleeson



Drug Discovery and Development (1)
Concurrent Session C6 Yasuko Hiraoka Myer Room



4:00 PM - 5:40 PM

Chaired by Prof David Adams and Dr Ruchong Ou


4:00pm
Open Innovation in Diversified Healthcare Business


Dr Mingde Xia
4:20pm
Analgesic conotoxins: Modulation of voltage-gated calcium channels in pain pathways


Prof David Adams
4:40pm
Ligand-directed signalling bias at G protein coupled receptors and its potential for new
therapeutics


Prof. Roger Summers
5:00pm
From Single Target to Multi Targets: A New Drug Discovery Paradigm
Prof. Jun Xu
5:20pm
Nucleocytoplasmic Trafficking as a Target for Anti-virals


Prof. David Jans
5:40pm
Status of Randomized Clinical Trials on Traditional Chinese Medicine in China and the
Strategy for Improvement
Prof. Jianping Liu




Oral Presentation (1)
G02-G03









4:00 PM - 5:50 PM

Chaired by A/Prof Rose Ffrench and Prof Chang Chen

4:00pm
ImmunoMonitoring Facility providing specialised assays of immune function to support
the development of novel vaccines and immunotherapies

A/Prof Rose Ffrench
4:15pm
Subtotal nephrectomy accelerates pathological cardiac remodelling post myocardial
infarction: A new model of cardiorenal syndrome?

Shan Liu






4:30pm
Multi-omics landscape of clear cell renal carcinoma

Dr Ying Liu
4:45pm
Molecular profiling comparison of the structure of intestinal bacterial community in
diarrhea patients infected with different viruses

Dr Jiru Xu

---

5:00pm
Suppressive effect of green tea on systolic blood pressure and cardiovascular damage in
spontaneously hypertensive rat.

Dr Yue-Rong Liang
5:15pm
Plcd1 and its modifier genes are responsible for the hair density of mouse

Dr Baojin Wu





5:30pm
The synthesis and antitumor bioactivities of novel carbohydrated-benzothiazole
compounds in drug discovery

Dr Pengfei Zhang



Conference Dinner: Dynasty Sea Food Restaurant, Level 1, 206 Bourke Street, Melbourne
Restaurant
7:00 PM - 10:00 PM

Saturday, 30th April
Registration
Main Foyer Carrillo Gantner Theatre
9:00 AM - 11:00 AM



Plenary Lecture
Plenary Session P3 Carrillo Gantner Theatre
9:00 AM - 10:30 AM
Chaired by Prof. Ye-Guang Chen and Prof Kou-Juey Wu

9:00am
A oligomers as tractable targets for Alzheimer's disease diagnostics and therapeutics.


Professor Colin Masters
9:30am
Angiomotin-like 2 plays important roles in gastrula cell movements and angiogenesis in
the zebrafish embryos


Prof. Anming Meng
10:00am
New insights into the domains and dynamics of the plasma membrane


Professor Rob Parton


Morning Tea












10:30 AM - 11:00 AM

Drug Discovery & Development (2)
Concurrent Session C7 Carrillo Gantner Theatre



11:00 AM - 1:20 PM

Chaired by Dr Mingde Xia and A/Prof Chun Guang Li

11:00am
Regulation of the pain-transducing ion channel TRPV1 by post-translational modification:
New targets for analgesics?

Prof. Peter McIntyre
11:20am
Selective immunosuppression realized by natural products

Prof. Qiang Xu






11:40pm
Novel Small-Molecule AMPK Activator Ameliorates Metabolic Syndrome


Prof Jia Li
12:00pm
G-Protein Coupled Receptors transactivate the serine/threonine kinase Transforming
Growth Factor -Type I Receptor in Vascular Smooth Muscle


Prof. Peter Little
12:20pm
Drug discovery: The potential role of classical literature of herbal medicine

Prof Charlie Xue

---

12:40pm
Ginger- A Spice with New Life in Diabetes and Metabolic Syndrome
Status of Randomized Clinical Trials on Traditional Chinese Medicine in China and the
Strategy for Improvement


Prof Basil Roufogalis



Neuroscience
Concurrent Session C8 Yasuko Hiraoka Myer Room



11:00 AM - 1:20 PM

Chaired by Prof. Terence J. O'Brien and Prof Shigang He

11:00am
Overview of frontotemporal dementia


Prof Glenda Halliday
11:20am
Roles of p75NTR and neurotrophins in the development of Alzheimer's disease


A/Prof Xin Fu Zhou
11:40pm
A Novel Mechanism of Neurodegeneration in Familal Polyneuropathy
Dr. Robert Gasperini
12:00pm
AAV mediated gene therapy rescues retinal ganglion cells and visual function after acute
elevation of intraocular pressure


Prof Shigang He
12:20pm
Utilizing rat models to understand polygenic determinants of idiopathic generalised
epilepsy phenotypes


Prof. Terence J. O'Brien
12:40pm
Analysis for the relevance of asthma susceptibility with the alteration and expression
defect in integrin 4


Prof Xiaoqun Qin
1:00pm
Developing new drugs for Parkinson's Diseases
A/Prof David Finkelstein


Lunch

1:20 PM - 1:50 PM

ACABS Cutting Edge Research
Concurrent Session C9 Carrillo Gantner Theatre




1:50 PM - 4:00 PM

Chaired by A/Prof Chunguang Li and A/Prof Jiming Ye

1:40pm Prof Chen Chen
2:00pm A/Prof Weisan Chen
2:20pm Dr Die Yu
2:40pm Dr Binghui Wang
3:00 pm Dr Hongjian Zhu
3:20 pm A/Prof Jiming Ye
3:40 pm Prof Jun-Ping Liu

Oral Presentation (2)
Concurrent Session C10 Yasuko Hiraoka Myer Room



2:00 PM - 3:45 PM

Chaired by A/Prof Rose Ffrench and Prof Chang Chen

2:00pm
The role of c-Src tyrosine kinase in glutamate-induced excitotoxic neuronal cell death
Mohammed Iqbal Hossain
2;15pm
Serial analysis of gene expression in osteoblasts treated by cyclic stretching

Dr Huan Liu
2:30pm
Insulin-like Growth Factor Transport and Competitive Binding in Articular Cartilage

---

Dr Lihai Zhang



2:45pm
BAMBI knockdown enhances adipogenesis of human preadipocytes (hPAs)

Xiao Luo
3:00pm
In vitro antioxidant property of Cissus quadrangularis L. stem in methanolic extract and
its fractions


Krunal Nagani
3:15pm
Tea polyphenols protection against UVB-induced damage to human retinal pigment
epithelial cells in vitro


Jian-hui Ye


3:30pm
Mechanism of Improvement in Vagus against Myocardial Ischemic Injury

Dr Lei Sun (poster)
3:35pm
Participation of NF-kappaB in neuropeptide Y and proopiomelanocortin gene expressions
and in the regulation of amphetamine-mediated behavioral response


Dong-Yih Kuo (poster)
3:40pm
Searching for miRNA Signatures Distinguishing Adult Stem Cells from Fibroblast Cells
Dr Xiaobing Wu (poster)



Award Presentation
Carrillo Gantner Theatre
4:00pm-4:15pm
With Main sponsors

---