Effect of daidzein, a soy isoflavone, on bone metabolism in Cd treated ovariectomized rats
This study compared the ability of daidzein, a soy isoflavone, with that of 17?-estradiol to pre-vent bone loss in cadmium (Cd)-exposed ovariectomized (OVX) rats during growth. Four week-
old female Wistar rats were randomly assigned to five treatment groups of 9 rats each, either
(1) sham-operated (SH); (2) OVX and placed on experimental diets (OVX); (3) OVX fed 50 ppm
of CdCl2 (OVX-Cd); (4) OVX fed 50 ppm of CdCl2 and 10 µg of daidzein per kg of body mass
(OVX-CD-D); or (5) OVX fed 50 ppm of CdCl2 and 10 µg of estrogen per kg of body mass (OVX-
CD-E). All rats were given free access to AIN-76 modified diet and drinking water, with or
without Cd, for 8 weeks. The OVX groups gained more (P < 0.05) body mass than the SH group.
Femoral mass was increased by feeding daidzein and estradiol, whereas femoral length was
not (P > 0.05) significantly different among groups. Femoral breaking force was not significantly
different among groups, however, femoral BMD was significantly lower in OVX-Cd than in the
SH and OVX groups. Morphologically proliferative cartilage and hypertrophic cells in femur
showed normal distribution in OVX-Cd-D and OVX-Cd-E groups unlike those in OVX-Cd group.
These findings suggest that Cd-OVX-induced osteopenia or osteoporosis probably results from
an increase in bone turnover.
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Effects of Dietary Isoflavone-extract from Soybean Hypocotyl on Bone Metabolism in Ovariectomized Young and Old Female Rats 
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