Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats

Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats. Tjahjono K*, Setyawati AN*, Novyanto R**, Angelo M**, Pratama MFR**, Dinayanti T** *Department of Biochemistry, Faculty of Medicine Diponegoro University, Semarang, Indonesia **Faculty of Medicine Diponegoro University, Semarang, Indonesia Background: WHO has estimated CVD Method: This was an experiment with pre and -(Cerebrovascular disease) by 2010 to be the most post randomized controlled group design, using leading death factor worldwide. This reflects a hypercholesterolemic male Sprague-dawley rats, significant change in diet habits, physical activity which were divided into 4 groups, the first group levels, and tobacco consumption worldwide. High was placebo (P) with normal feeding, the others blood pressure, high blood cholesterol, overweight were with levelled-up additional feeding of 125 and obesity - and the chronic disease of type 2 mg/Kg weight/day (T1), 250 mg/Kg weight/day diabetes are among the major biological risk (T2), and 500 mg/Kg weight/day (T3). Total factors for CVD. Hibiscus sabdariffa is traditionally cholesterol and HDL were analyzed with GPO-PAP believed to improve hyperlipidemic condition. This method and triglyceride was with Friedewald study was conducted to look for the hypolipidemic method effect of Hibiscus sabdariffa and the dose given difference outcome. Table. Mean pre-and post-treatment values of lipid profile. Result: Post hoc LSD analysis showed that the total cholesterol, LDL and triglyceride were with significant difference between pre and post- experimental paired groups [total cholesterol; LDL; triglyceride, subsequently with p: 0.000; p: 0,000; p:0,000]. There was also a significant increment on HDL cholesterol (p: 0.000). Discussion: The hypolipidemic of Hibiscus sabdariffa between pre and post- experimental is assumed due to pectin, niacin, anthosianin, dan β-sitosterol containment. These active H. sabdariffa flower compounds have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and catalytic activity rate of cholesterol which may explain the hypolipidemic effect of Hibiscus sabdariffa. Keyword: Hibiscus sabdariffa, hypercholesterolemia, lipid profile Reference: 1. C.M. Gurrola-Dı´az, et. al. Effect of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid Conclusion: The hypolipidemic of Hibiscus profiles of patients with Metabolic Syndrome (MeSy). sabdariffa between pre and post- experimental is Phytomedicine.17, 500–5. assumed due to pectin, niacin, anthosianin, dan 2. Chen CC, et.al. Hibiscus sabdariffa extract inhibits the β-development of atherosclerosis in sitosterol containment. These active compounds cholesterol-fedrabbits.J.Agric.FoodChem.51,5472–5477 have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and catalytic activity rate of cholesterol which may Presented in the Indonesian Medical Doctor explain the hypolipidemic effect of Hibiscus Nutrition Society) National Congress, sabdariffa. Semarang, October 15-17th, 2010