Thursday – Section 4
April 7, 2011
What is Myasthenia Gravis?
Who can be diagnosed with Myasthenia
How can it be treated?
Clinical study of a treatment drug
A chronic autoimmune neuromuscular disease that
causes different degrees of voluntary muscle weakness
throughout the body.
Antibodies produced by our own immune system
destroy, block, or alter acetylcholine receptors at the
neuromuscular junction which put a stop to a contraction
of a muscle.
Population most commonly affected are young adult
women and older men, but can occur in anyone
regardless of age and race.
Image Credit: http://www.myasthenia-gbspk.org/res.aspx
Prograf (Tacrolimus) – Top 200 drug
Therapeutic Class – Immunosuppressant
Adverse Effects : Headache, Constipation, Nausea
Therapeutic Class – Anticholinesterase
Adverse Effects: Excessive salivation, Muscle
20Years from Diagnosis
Reference: Christensen, P. B., Jensen, T. S., Tsiropoulos, I. I., Sorensen, T. T., Kjaer, M. M., Hojer-Pedersen, E. E., &
... Lehfeldt, E. E. (1998). Mortality and survival in myasthenia gravis: A Danish population based study.Journal of
Neurology Neurosurgery and Psychiatry, 64(1), 78-83.
StudyA clinical study for the use of tacrolimus to treat myasthenia gravis
212 patients with myasthenia
Improvement of muscular
strength in a large amount of
patients with MG
Tacrolimus in low-doses proved to
be effective for treatment
Muscular strength improvement is
a great factor for patient
compliance for this drug.
Christensen, P. B., Jensen, T. S., Tsiropoulos, I. I., Sorensen, T. T.,
Kjaer, M. M., Hojer-Pedersen, E. E., & ... Lehfeldt, E. E. (1998).
Mortality and survival in myasthenia gravis: A Danish population
based study.Journal of Neurology Neurosurgery and Psychiatry
Micromedex – Search Drug name for Adverse Effects
Myasthenia Gravis Fact Sheet: National Institute of Neurological
Disorders and Stroke (NINDS). (n.d.).National Institute of Neurological Disorders and Stroke (NINDS)
. Retrieved March 28,
Ponseti, J., Gamez, J., Azem, J., López-Cano, M., Vilallonga, R., &
Armengol, M. (2008). Tacrolimus for myasthenia gravis: a clinical
study of 212 patients. Annals Of The New York Academy Of Sciences
1132254-263. Retrieved from EBSCOhost
PMWO : Pakistan Myasthenia Gravis Welfare Organization .
(n.d.). PMWO :: Pakistan Myasthenia Gravis Welfare Organization
Retrieved March 28, 2011, from http://www.myasthenia-