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  • Added: April, 07th 2011
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Menstruation and Pregnancy in Women with Myasthenia Gravis

by: ville, 2 pages

The purpose of this booklet is to provide women diagnosed with myasthenia gravis (MG) with information about the influence and relationship MG has on the reproductive system. It contains information ...

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Johnny Nguyen
Thursday – Section 4
April 7, 2011

 What is Myasthenia Gravis?
 Who can be diagnosed with Myasthenia
Gravis?
 How can it be treated?
 Clinical study of a treatment drug

 Definition
 A chronic autoimmune neuromuscular disease that
causes different degrees of voluntary muscle weakness
throughout the body.
 Pathophysiology
 Antibodies produced by our own immune system
destroy, block, or alter acetylcholine receptors at the
neuromuscular junction which put a stop to a contraction
of a muscle.
 Prevalence
 Population most commonly affected are young adult
women and older men, but can occur in anyone
regardless of age and race.
 Symptoms

Image Credit: http://www.myasthenia-gbspk.org/res.aspx

 Pharmacological Treatment
 Prograf (Tacrolimus) – Top 200 drug
 Therapeutic Class – Immunosuppressant
 Adverse Effects : Headache, Constipation, Nausea
 Prostigmin(Neostigmine Bromide)
 Therapeutic Class – Anticholinesterase
 Adverse Effects: Excessive salivation, Muscle
fasciculation
 Non-pharmacological Treatment
 Plasmapheresis
 Thymectomy

120
100
) 80
a
l (%
60
Thymectomised
S
u
r
v
iv

40
Non-Thymectomised
20
0
0
3
5
10
20
Years from Diagnosis
Reference: Christensen, P. B., Jensen, T. S., Tsiropoulos, I. I., Sorensen, T. T., Kjaer, M. M., Hojer-Pedersen, E. E., &
... Lehfeldt, E. E. (1998). Mortality and survival in myasthenia gravis: A Danish population based study.Journal of
Neurology Neurosurgery and Psychiatry, 64(1), 78-83.

Study
A clinical study for the use of
tacrolimus to treat myasthenia
gravis
Methods
212 patients with myasthenia
gravis
nonrandomized and
noncontrolled
study
Finding/Results
Improvement of muscular
strength in a large amount of
patients with MG
Conclusions
Tacrolimus in low-doses proved to
be effective for treatment
Personal Perspective
Muscular strength improvement is
a great factor for patient
compliance for this drug.


Christensen, P. B., Jensen, T. S., Tsiropoulos, I. I., Sorensen, T. T.,
Kjaer, M. M., Hojer-Pedersen, E. E., & ... Lehfeldt, E. E. (1998).
Mortality and survival in myasthenia gravis: A Danish population
based study.Journal of Neurology Neurosurgery and Psychiatry, 64(1),
78-83.

Micromedex – Search Drug name for Adverse Effects

Myasthenia Gravis Fact Sheet: National Institute of Neurological
Disorders and Stroke (NINDS). (n.d.).National Institute of
Neurological Disorders and Stroke (NINDS). Retrieved March 28,
2011, from
http://www.ninds.nih.gov/disorders/myasthenia_gravis/detail_
myasthenia_gravis.htm

Ponseti, J., Gamez, J., Azem, J., López-Cano, M., Vilallonga, R., &
Armengol, M. (2008). Tacrolimus for myasthenia gravis: a clinical
study of 212 patients. Annals Of The New York Academy Of Sciences,
1132254-263. Retrieved from EBSCOhost.

PMWO : Pakistan Myasthenia Gravis Welfare Organization .
(n.d.). PMWO :: Pakistan Myasthenia Gravis Welfare Organization .
Retrieved March 28, 2011, from http://www.myasthenia-
gbspk.org/res.aspx

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