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volume of distribution

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intracellular fluid.

body water and can never exceed body water.

Plasma

3 - 4

Interstitial

10 - 13

Intracellular

25 - 28

Total body water

40 - 46

volume. This would happen only if the drug is

uniformly

same and the Volume is the

same as the size of the

beaker.

equilibrium, distribution b/n

the solution and the charcoal

may be complete. However,

drug conc. within the beaker

is not uniform. Much of the

drug

theoretical volume of fluid (not only plasma) into

which the total drug administered would have to

be diluted to produce the concentration in

plasma.

the actual volume of the body or its fluid

compartments

comparatively little of a dose remains in the

circulation to be measured; thus, plasma

concentration is low and volume of distribution

is high. Drugs that remain in the circulation tend

to have a low volume of distribution.

the plasma concentration expected for a given

dose. Each drug is uniquely distributed in the

body. Some drugs distribute mostly into fat,

others remain in ECF, and others are bound

extensively to specific tissues.

protein-bound and thus have a small volume of

distribution.

extensively taken up by tissues and thus have a

volume of distribution larger than the volume of

the entire body.

plasma concentration. A parameter used to define the

process of distribution and called "the apparent volume

of distribution (V )".

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