Many drugs of abuse produce changes in impulsive choice, that is, choice for a smaller–sooner reinforcer over a larger–later reinforcer. Because the alternatives differ in both ...
The generalized matching law provides precise descriptions of choice, but has not been used to characterize choice between different doses of drugs or different classes of drugs. The current ...
Six experimentally naive rhesus monkeys produced 0.01 mg/kg/infusion cocaine by lever pressing under a tandem fixed-ratio 1 differential-reinforcement-of-other-behavior schedule. One lever ...
Learning and memory are central topics in behavioral neuroscience, and inbred mice strains are widely investigated. However, operant conditioning techniques are not as extensively used in this ...
Children who have status epilepticus have continuous or rapidly repeating seizures that may be life- threatening and may cause life-long changes in brain and behavior. The extent to which ...
Dose-dependent changes in sensitivity to reinforcement were found when rats were treated with low, moderate, and high doses of the partial dopamine D1-type receptor agonist SKF38393 and with ...
Rate-dependent drug effects have been observed for operant responding maintained by food, water, heat, light onset, electrical brain stimulation, shock-stimulus termination, and shock ...
The effects of manipulations of response requirement, intertrial interval (ITI), and psychoactive drugs (ethanol, phencyclidine, and d-amphetamine) on lever choice under concurrent ...
Rats were trained, under a two-lever drug-discrimination procedure, to respond differentially de- pending upon whether lorazepam (1.0 mg/kg) or no injection had been administered before the
Four rats responded under a simple fixed consecutive number schedule in which eight or more consecutive responses on the run lever, followed by a single response on the reinforcement lever,